The insect-killing bacterium Photorhabdus luminescens has the lowest mutation rate among bacteria.

ABSTRACT: Mutation is a primary source of genetic variation that is used to power evolution. Many studies, however, have shown that most mutations are deleterious and, as a result, extremely low mutation rates might be beneficial for survival. Using a mutation accumulation experiment, an unbiased method for mutation study, we found an extremely low base-substitution mutation rate of 5.94 × 10^-11 per nucleotide site per cell division (95% Poisson confidence intervals: 4.65 × 10^-11, 7.48 × 10^-11) and indel mutation rate of 8.25 × 10^-12 per site per cell division (95% confidence intervals: 3.96 × 10^-12, 1.52 × 10^-11) in the bacterium Photorhabdus luminescens ATCC29999. The mutations are strongly A/T-biased with a mutation bias of

SUBMITTER: Pan J 

PROVIDER: S-EPMC8009600 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature