Using the Key Characteristics of Carcinogens to Develop Research on Chemical Mixtures and Cancer.

ABSTRACT:

Background

People are exposed to numerous chemicals throughout their lifetimes. Many of these chemicals display one or more of the key characteristics of carcinogens or interact with processes described in the hallmarks of cancer. Therefore, evaluating the effects of chemical mixtures on cancer development is an important pursuit. Challenges involved in designing research studies to evaluate the joint action of chemicals on cancer risk include the time taken to perform the experiments because of the long latency and choosing an appropriate experimental design.

Objectives

The objectives of this work are to present the case for developing a research program on mixtures of environmental chemicals and cancer risk and describe recommended approaches.

Methods

A working grou

SUBMITTER: Rider CV 

PROVIDER: S-EPMC8009606 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature