Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice.

ABSTRACT: Methionine restriction (MR) dramatically extends the healthspan of several organisms. Methionine-restricted rodents have less age-related pathology and increased longevity as compared with controls, and recent studies suggest that humans might benefit similarly. Mechanistically, it is likely that the decreased IGF-1 signaling that results from MR underlies the benefits of this regimen. Thus, we hypothesized that interventions that decrease IGF-1 signaling would also produce MR-like healthspan benefits. Selenium supplementation inhibits IGF-1 signaling in rats and has been studied for its putative healthspan benefits. Indeed, we show that feeding mice a diet supplemented with sodium selenite results in an MR-like phenotype, marked by protection against diet-induced obesity, as well as alter

SUBMITTER: Plummer JD 

PROVIDER: S-EPMC8009673 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature