Bioinformatic Analysis of Key Genes and Pathways Related to Keloids.

ABSTRACT:

Background

The pathophysiology of keloids is complex, and the treatment for keloids is still an unmet medical need. Our study is aimed at identifying the hub genes among the differentially expressed genes (DEGs) between normal skin tissue and keloids and key pathways in the development of keloids.

Materials and methods

We downloaded the GSE92566 and GSE90051 microarray data, which contain normal skin tissue and keloid gene expression data. GSE92566 was treated as a discovery dataset for summarizing the significantly DEGs, and GSE90051 served as a validation dataset. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway, Reactome enrichment analysis, gene set enrichment analysis, and gene set variation analysis were performed for the key functions and pathways enrich

SUBMITTER: Bi S 

PROVIDER: S-EPMC8009712 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature