Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration.

ABSTRACT: Hepatocyte proliferation is the principal mechanism for generating new hepatocytes in liver homeostasis and regeneration. Recent studies have suggested that this ability is not equally distributed among hepatocytes but concentrated in a small subset of hepatocytes acting like stem cells, located around the central vein or distributed throughout the liver lobule and exhibiting active WNT signaling or high telomerase activity, respectively. These findings were obtained by utilizing components of these growth regulators as markers for genetic lineage tracing. Here, we used random lineage tracing to localize and quantify clonal expansion of hepatocytes in normal and injured liver. We found that modest proliferation of hepatocytes distributed throughout the lobule maintains the hepatocyte mass

SUBMITTER: Chen F 

PROVIDER: S-EPMC8009755 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature