Prevalence and mortality in children with congenital diaphragmatic hernia: a multicountry study.

ABSTRACT:

Purpose

This study determined the prevalence, mortality, and time trends of children with congenital diaphragmatic hernia (CDH).

Methods

Twenty-five hospital- and population-based surveillance programs in 19 International Clearinghouse for Birth Defects Surveillance and Research member countries provided birth defects mortality data between 1974 and 2015. CDH cases included live births, stillbirths, or elective termination of pregnancy for fetal anomalies. Prevalence, cumulative mortality rates, and 95% confidence intervals (CIs) were calculated using Poisson regression and a Kaplan-Meier product-limit method. Joinpoint regression analyses were conducted to assess time trends.

Results

The prevalence of CDH was 2.6 per 10,000 total births (95% CI: 2.5-2.7), slightly in

SUBMITTER: Politis MD 

PROVIDER: S-EPMC8009766 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature