Targeting 5-HT_2B Receptor Signaling Prevents Border Zone Expansion and Improves Microstructural Remodeling After Myocardial Infarction.

ABSTRACT:

Background

Myocardial infarction (MI) induces an intense injury response that ultimately generates a collagen-dominated scar. Although required to prevent ventricular rupture, the fibrotic process is often sustained in a manner detrimental to optimal recovery. Cardiac myofibroblasts are the cells tasked with depositing and remodeling collagen and are a prime target to limit the fibrotic process after MI. Serotonin 2B receptor (5-HT_2B) signaling has been shown to be harmful in a variety of cardiopulmonary pathologies and could play an important role in mediating scar formation after MI.

Methods

We used 2 pharmacological antagonists to explore the effect of 5-HT_2B inhibition on outcomes after MI and characterized the histological and microstructural chang

SUBMITTER: Snider JC 

PROVIDER: S-EPMC8009826 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature