Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs.

ABSTRACT: Most cells constitutively secrete mitochondrial DNA and proteins in extracellular vesicles (EVs). While EVs are small vesicles that transfer material between cells, Mitochondria-Derived Vesicles (MDVs) carry material specifically between mitochondria and other organelles. Mitochondrial content can enhance inflammation under pro-inflammatory conditions, though its role in the absence of inflammation remains elusive. Here, we demonstrate that cells actively prevent the packaging of pro-inflammatory, oxidized mitochondrial proteins that would act as damage-associated molecular patterns (DAMPs) into EVs. Importantly, we find that the distinction between material to be included into EVs and damaged mitochondrial content to be excluded is dependent on selective targeting to one of two distinct M

SUBMITTER: Todkar K 

PROVIDER: S-EPMC8009912 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature