Antibodies Targeting the Transferrin Receptor 1 (TfR1) as Direct Anti-cancer Agents.

ABSTRACT: The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron uptake through the interaction with iron-bound Tf. Iron is required for multiple cellular processes and is essential for DNA synthesis and, thus, cellular proliferation. Due to its central role in cancer cell pathology, malignant cells often overexpress TfR1 and this increased expression can be associated with poor prognosis in different types of cancer. The elevated levels of TfR1 expression on malignant cells, together with its extracellular accessibility, ability to internalize, and central role in cancer cell pathology make this receptor an attractive target for antibody-mediated therapy.

SUBMITTER: Candelaria PV 

PROVIDER: S-EPMC8010148 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature