Evaluation of Renal Fibrosis by Mapping Histology and Magnetic Resonance Imaging.

ABSTRACT:

Background

Renal fibrosis is a key driver of progression in chronic kidney disease (CKD). Recent advances in diagnostic imaging techniques have shown promising results for the noninvasive assessment of renal fibrosis. However, the specificity and accuracy of these techniques are controversial because they indirectly assess renal fibrosis. This limits fibrosis assessment by imaging in CKD for clinical practice. To validate magnetic resonance imaging (MRI) assessment for fibrosis, we derived representative models by mapping histology-proven renal fibrosis and imaging in CKD.

Methods

Ninety-seven adult Chinese CKD participants with histology were studied. The kidney cortex interstitial extracellular matrix volume was calculated by the Aperio ScanScope system using Masson's tric

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8010230 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature