Dysfunction of the Auditory Brainstem as a Neurophysiology Subtype of Autism Spectrum Disorder.

ABSTRACT: Autism spectrum disorder (ASD) is very heterogeneous, particularly in language. Studies have suggested that language impairment is linked to auditory-brainstem dysfunction in ASD. However, not all ASD children have these deficits, which suggests potential subtypes of ASD. We classified ASD children into two subtypes according to their speech-evoked auditory brainstem response (speech-ABR) and explored the neural substrates for possible subtypes. Twenty-nine children with ASD and 25 typically developing (TD) peers were enrolled to undergo speech-ABR testing and structural magnetic resonance imaging (sMRI). There were significant differences between the ASD group and TD group in surface area, cortical volume and cortical thickness. According to speech-ABR results, ASD participants were divid

SUBMITTER: Chen J 

PROVIDER: S-EPMC8010248 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature