Excluded versus included patients in a randomized controlled trial of infections caused by carbapenem-resistant Gram-negative bacteria: relevance to external validity.

ABSTRACT:

Background

Population external validity is the extent to which an experimental study results can be generalized from a specific sample to a defined population. In order to apply the results of a study, we should be able to assess its population external validity. We performed an investigator-initiated randomized controlled trial (RCT) (AIDA study), which compared colistin-meropenem combination therapy to colistin monotherapy in the treatment of patients infected with carbapenem-resistant Gram-negative bacteria. In order to examine the study's population external validity and to substantiate the use of AIDA study results in clinical practice, we performed a concomitant observational trial.

Methods

The study was conducted between October 1st, 2013 and January 31st, 2017 (durin

SUBMITTER: Daitch V 

PROVIDER: S-EPMC8010276 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature