Regulation of dual oxidase hydrogen peroxide synthesis results in an epithelial respiratory burst.

ABSTRACT: Redox status is a central determinant of cellular activities and redox imbalance is correlated with numerous diseases. NADPH oxidase activity results in formation of H₂O₂, that, in turn, sets cellular redox status, a key regulator of cellular homeostasis and responses to external stimuli. Hydrogen peroxide metabolism regulates cell redox status by driving changes in protein cysteine oxidation often via cycling of thioredoxin/peroxiredoxin and glutathione; however, regulation of enzymes controlling synthesis and utilization of H₂O₂ is not understood beyond broad outlines. The data presented here show that calcium-stimulated epithelial Duox H₂O₂ synthesis is transient, independent of intracellular calcium renormalization, H

SUBMITTER: Conner GE 

PROVIDER: S-EPMC8010520 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature