Injectable bone cement with magnesium-containing microspheres enhances osteogenesis via anti-inflammatory immunoregulation.

ABSTRACT: Injectable bone cement is especially useful in minimally invasive surgeries to repair small and irregular bone defects. Amongst different kinds of injectable bone cements, bioactive calcium phosphate bone cement (CPC) has been widely studied due to its biological activity. However, its dense structure and poor biodegradability prevent the ingrowth of living tissue, which leads to undesirable bone regeneration and clinical translation. To address this issue, we prepared bone cement based on Magnesium-containing microspheres (MMSs) that can not only be cured into a 3D porous scaffold but also have controllable biodegradability that continuously provides space for desired tissue ingrowth. Interestingly, magnesium ions released from MMSs cement (MMSC) trigger positive immunomodulation via upre

SUBMITTER: Tan S 

PROVIDER: S-EPMC8010581 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature