Risk Factors for Syncope Associated With Multigenerational Relatives With a History of Syncope.

ABSTRACT:

Importance

Reflex syncope is the major cause of transient loss of consciousness, which affects one-third of the population, but effective treatment for individuals with severe syncope is lacking. Better understanding of reflex syncope predisposition may offer new therapeutic solutions.

Objectives

To determine the familial risk of syncope in first-, second-, and third-degree relatives of affected individuals and to explore the role of genes and family environment in reflex syncope.

Design, setting, and participants

In this national population-based family cohort study, the Swedish multigeneration register was linked to 3 Swedish nationwide registers: hospital discharge, outpatient care, and primary care registers for the period from 1997 to 2015. Sibling pairs born to

SUBMITTER: Fedorowski A 

PROVIDER: S-EPMC8010588 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature