Effect of hypertonic saline in the management of elevated intracranial pressure in children with cerebral edema: A systematic review and meta-analysis.

ABSTRACT:

Objective

To determine the hypertonic saline efficacy in children with cerebral edema and raised intracranial pressure.

Method

Studies assessing the efficacy and safety of hypertonic saline in children with cerebral edema and elevated intracranial pressure were identified using Medline, Web of Science, Scopus, and Google Scholar databases. Two reviewers independently assessed papers for inclusion. The primary outcome was a reduction of elevated intracranial pressure by the administration of hypertonic saline.

Results

We initially evaluated 1595 potentially relevant articles, and only 7 studies met the eligibility criteria for the final analysis. Out of the seven studies, three of them were randomized controlled trials. Three of the studies found that hypertonic saline

SUBMITTER: Afroze F 

PROVIDER: S-EPMC8010820 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature