Immune checkpoint inhibitor-induced aseptic meningitis and encephalitis: a case-series and narrative review.

ABSTRACT:

Background

Along with the increasing use of immune checkpoint inhibitors comes a surge in immune-related toxicity. Here, we review the currently available data regarding neurological immune adverse events, and more specifically aseptic meningitis and encephalitis, and present treatment and diagnostic recommendations. Furthermore, we present five cases of immunotherapy-induced aseptic meningitis and encephalitis treated at our institution.

Recent findings

Neurological immune-related adverse events, including aseptic meningitis and encephalitis, secondary to checkpoint inhibitors are a rare but complex and clinically relevant entity, comprising a wide range of diseases, most often presenting with symptoms with a wide range of differential diagnoses. Our case-series highlights

SUBMITTER: Thouvenin L 

PROVIDER: S-EPMC8010823 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature