Abnormal large-scale structural rich club organization in Leber's hereditary optic neuropathy.

ABSTRACT:

Objective

The purpose of this study was to investigate whether the large-scale structural rich club organization was abnormal in patients with Leber's hereditary optic neuropathy (LHON) using diffusion tensor imaging (DTI), and the associations among disrupted brain structural connectivity, disease duration, and neuro-ophthalmological impairment.

Methods

Nineteen acute, 34 chronic LHON patients, and 36 healthy controls (HC) underwent DTI and neuro-ophthalmological measurements. The brain structural network and rich club organization were constructed based on deterministic fiber tracking at the individual level. Then intergroup differences among the acute, chronic LHON patients and healthy controls (HC) in three types of structural connections, including rich club, feeder, an

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8010853 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature