Efficacy of quetiapine for delirium prevention in hospitalized older medical patients: a randomized double-blind controlled trial.

ABSTRACT:

Background

Delirium is a common disorder among hospitalized older patients and results in increased morbidity and mortality. The prevention of delirium is still challenging in older patient care. The role of antipsychotics in delirium prevention has been limited. Therefore, we conducted a trial to investigate the efficacy of quetiapine use to prevent delirium in hospitalized older medical patients.

Methods

This study was a randomized double-blind controlled trial conducted at Ramathibodi Hospital, Bangkok, Thailand. Patients aged ≥65 years hospitalized in the internal medicine service were randomized to quetiapine 12.5 mg or placebo once daily at bedtime for a maximum 7-day duration. The primary end point was delirium incidence. Secondary end points were delirium duration, l

SUBMITTER: Thanapluetiwong S 

PROVIDER: S-EPMC8010962 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature