Acute Kidney Injury among Black Patients with Sickle Cell Trait and Sickle Cell Disease.

ABSTRACT:

Background and objectives

Sickle cell trait and sickle cell disease are associated with faster GFR decline compared with normal hemoglobin phenotypes. We sought to compare the AKI risk in sickle cell trait/disease to normal hemoglobin phenotypes and investigate the association between AKI and GFR decline in sickle cell trait/disease.

Design, setting, participants, & measurements

This multicenter observational study used registry data (January 2005-June 2018) of adult Black patients with sickle cell trait/disease (exposures) and normal hemoglobin phenotype (reference) ascertained by hemoglobin electrophoresis. Outcomes of interest (incident AKI [1.5 times baseline serum creatinine or higher], incident severe AKI [doubling of baseline serum creatinine or higher], and incident

SUBMITTER: Olaniran KO 

PROVIDER: S-EPMC8011026 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature