Role of suppression of endometriosis with progestins before IVF-ET: a non-inferiority randomized controlled trial.

ABSTRACT:

Background

Endometriosis affects the responsiveness to ovarian stimulation. This study aimed to assess the role of Dienogest pretreatment for endometriosis suppression as compared to Gonadotropin-releasing hormone agonist (GnRHa) in patients with endometriosis pursuing IVF treatment.

Methods

In this randomized controlled trial, 134 women with endometriosis-related infertility were randomly allocated to group A (n = 67) who had monthly depot GnRHa for 3 months before ovarian stimulation in IVF treatment (Ultra-long protocol), and Group B (n = 67) who had daily oral Dienogest 2 mg/d for 3 months before starting standard long protocol for IVF. The primary outcome measure was the number of oocytes retrieved. The secondary outcome measures included the number of mature oocytes, f

SUBMITTER: Khalifa E 

PROVIDER: S-EPMC8011082 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature