Identification and development of an independent immune-related genes prognostic model for breast cancer.

ABSTRACT:

Background

Breast cancer is one of the main malignant tumors that threaten the lives of women, which has received more and more clinical attention worldwide. There are increasing evidences showing that the immune micro-environment of breast cancer (BC) seriously affects the clinical outcome. This study aims to explore the role of tumor immune genes in the prognosis of BC patients and construct an immune-related genes prognostic index.

Methods

The list of 2498 immune genes was obtained from ImmPort database. In addition, gene expression data and clinical characteristics data of BC patients were also obtained from the TCGA database. The prognostic correlation of the differential genes was analyzed through Survival package. Cox regression analysis was performed to analyze the p

SUBMITTER: Chen L 

PROVIDER: S-EPMC8011146 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature