Comprehensive analysis of immune-related prognostic genes in the tumour microenvironment of hepatocellular carcinoma.

ABSTRACT:

Background

The mortality rate of hepatocellular carcinoma (HCC) remains high worldwide despite surgery and chemotherapy. Immunotherapy is a promising treatment for the rapidly expanding HCC spectrum. Therefore, it is necessary to further explore the immune-related characteristics of the tumour microenvironment (TME), which plays a vital role in tumour initiation and progression.

Methods

In this research, 866 immune-related differentially expressed genes (DEGs) were identified by integrating the DEGs of samples from The Cancer Genome Atlas (TCGA)-HCC dataset and the immune-related genes from databases (InnateDB; ImmPort). Afterwards, 144 candidate prognostic genes were defined through weighted gene co-expression network analysis (WGCNA).

Results

Seven immune-related pr

SUBMITTER: Gao W 

PROVIDER: S-EPMC8011181 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature