Transcription initiation of distant core promoters in a large-sized genome of an insect.

ABSTRACT:

Background

Core promoters have a substantial influence on various steps of transcription, including initiation, elongation, termination, polyadenylation, and finally, translation. The characterization of core promoters is crucial for exploring the regulatory code of transcription initiation. However, the current understanding of insect core promoters is focused on those of Diptera (especially Drosophila) species with small genome sizes.

Results

Here, we present an analysis of the transcription start sites (TSSs) in the migratory locust, Locusta migratoria, which has a genome size of 6.5 Gb. The genomic differences, including lower precision of transcription initiation and fewer constraints on the distance from transcription factor binding sites or regulatory elements to TSSs

SUBMITTER: Liu Q 

PROVIDER: S-EPMC8011201 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature