PD-L1 tumour expression is predictive of pazopanib response in soft tissue sarcoma.

ABSTRACT:

Background

Pazopanib, a multitargeted tyrosine kinase inhibitor, is recommended as the standard treatment for refractory soft tissue sarcoma (STS). However, there are comparatively few molecular determinants for predicting pazopanib efficacy. Based on correlative studies regarding the predictive impact of PD-L1, we investigated the clinical relevance of PD-L1 expression and evaluated its value for predicting pazopanib efficacy.

Methods

Tumour tissues from patients with advanced STS who went on to receive pazopanib were assessed for PD-L1 expression. Immunohistochemistry was performed using an anti-PD-L1 antibody, and the PD-L1 tumour proportion score (TPS) was calculated as the percentage of at least 100 viable cells with positive expression, defined as TPS ≥ 1%.

Results<

SUBMITTER: Kim SK 

PROVIDER: S-EPMC8011221 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature