Prostate cancer GTV delineation with biparametric MRI and ⁶⁸Ga-PSMA-PET: comparison of expert contours and semi-automated methods.

ABSTRACT:

Objective

The optimal method for delineation of dominant intraprostatic lesions (DIL) for targeted radiotherapy dose escalation is unclear. This study evaluated interobserver and intermodality variability of delineations on biparametric MRI (bpMRI), consisting of T₂ weighted (T₂W) and diffusion-weighted (DWI) sequences, and ⁶⁸Ga-PSMA-PET/CT; and compared manually delineated GTV contours with semi-automated segmentations based on quantitative thresholding of intraprostatic apparent diffusion coefficient (ADC) and standardised uptake values (SUV).

Methods

16 patients who had bpMRI and PSMA-PET scanning performed prior to any treatment were eligible for inclusion. Four observers (two radiation oncologists, two radiologists) manuall

SUBMITTER: Hearn N 

PROVIDER: S-EPMC8011238 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature