Association between ¹⁸F-FDG metabolic activity and programmed death ligand-1 (PD-L1) expression using 22C3 immunohistochemistry assays in non-small cell lung cancer (NSCLC) resection specimens.

ABSTRACT:

Objective

This study sought to investigate the association between ¹⁸F-fludeoxyglucose (¹⁸F-FDG) uptake in positron emission tomography/CT (PET/CT) scans and different programmed death ligand-1 (PD-L1) expression conditions in non-small cell lung cancer (NSCLC).

Methods

From October 2017 to December 2019, NSCLC was retrospectively identified in 419 consecutive patients who underwent ¹⁸F-FDG PET/CT scans and PD-L1 expression tests using the PD-L1 22C3 assay. The association between clinicopathological characteristics and PD-L1 expression was assessed.

Results

The frequency of PD-L1-positive tumours was 38.2% (160/419) in NSCLC. In NSCLC, the multivariate analysis showed a high maximum standardised uptake value (SUVmax) (p < 0.000

SUBMITTER: Zhao L 

PROVIDER: S-EPMC8011240 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature