Expanding the Thiol-X Toolbox: Photoinitiation and Materials Application of the Acid-Catalyzed Thiol-ene (ACT) Reaction.

ABSTRACT: The acid-catalyzed thiol-ene reaction (ACT) is a unique thiol-X conjugation strategy that produces S,X-acetal conjugates. Unlike the well-known radical-mediated thiol-ene and anion-mediated thiol-Michael reactions that produce static thioether bonds, acetals provide unique function for various fields such as drug delivery and protecting group chemistries; however, this reaction is relatively underutilized for creating new and unique materials owing to the unexplored reactivity over a broad set of substrates and potential side reactions. Solution-phase studies using a range of thiol and alkene substrates were conducted to evaluate the ACT reaction as a conjugation strategy. Substrates that efficiently undergo cationic polymerizations, such as those containing vinyl functional groups, were f

SUBMITTER: Sutherland BP 

PROVIDER: S-EPMC8011277 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature