Assessing Spatial Concordance Between Theranostic Pairs Using Phantom and Patient-Specific Acceptance Criteria: Application to ^99mTc-MAA SPECT/⁹⁰Y-Microsphere PET.

ABSTRACT:

Purpose

Predictive 3-dimensional dosimetry requires spatial concordance between diagnostic and therapeutic activity distributions. We assess similarity between theranostic pairs (^99mTc-macroaggregated albumin [MAA] single photon emission computed tomography [SPECT] and ⁹⁰Y microsphere positron emission tomography [PET]) in patients using criteria that account for spatial resolution differences and misregistration.

Methods and materials

Phantom-based acceptance criteria were determined using a liver phantom filled with ^99mTc and ⁹⁰YCl₃ and scanned with SPECT/computed tomography [CT] and PET/CT, respectively. Gaussian blurring was applied to PET to match ^99mTc phantom scan image quality. After rigid registration

SUBMITTER: Mikell JK 

PROVIDER: S-EPMC8011284 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature