Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans.

ABSTRACT: Circadian disruption has been identified as a risk factor for health disorders such as obesity, cardiovascular disease, and cancer. Although epidemiological studies suggest an increased risk of various cancers associated with circadian misalignment due to night shift work, the underlying mechanisms have yet to be elucidated. We sought to investigate the potential mechanistic role that circadian disruption of cancer hallmark pathway genes may play in the increased cancer risk in shift workers. In a controlled laboratory study, we investigated the circadian transcriptome of cancer hallmark pathway genes and associated biological pathways in circulating leukocytes obtained from healthy young adults during a 24-hour constant routine protocol following 3 days of simulated day shift or night shi

SUBMITTER: Koritala BSC 

PROVIDER: S-EPMC8011353 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature