Molecular Subtypes and CD4⁺ Memory T Cell-Based Signature Associated With Clinical Outcomes in Gastric Cancer.

ABSTRACT:

Background

CD4⁺ memory T cells are an important component of the tumor microenvironment (TME) and affect tumor occurrence and progression. Nevertheless, there has been no systematic analysis of the effect of CD4⁺ memory T cells in gastric cancer (GC).

Methods

Three datasets obtained from microarray and the corresponding clinical data of GC patients were retrieved and downloaded from the Gene Expression Omnibus (GEO) database. We uploaded the normalize gene expression data with standard annotation to the CIBERSORT web portal for evaluating the proportion of immune cells in the GC samples. The WGCNA was performed to identify the modules the CD4⁺ memory T cell related module (CD4⁺ MTRM) which was most significantly associated with CD4

SUBMITTER: Ning ZK 

PROVIDER: S-EPMC8011500 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature