Development of Empirical Bioavailability Models for Metals.

ABSTRACT: Recently, there has been renewed interest in the development and use of empirical models to predict metal bioavailability and derive protective values for aquatic life. However, there is considerable variability in the conceptual and statistical approaches with which these models have been developed. In the present study, we review case studies of empirical bioavailability model development, evaluating and making recommendations on key issues, including species selection, identifying toxicity-modifying factors (TMFs) and the appropriate environmental range of these factors, use of existing toxicity data sets and experimental design for developing new data sets, statistical considerations in deriving species-specific and pooled bioavailability models, and normalization of species sensitivit

SUBMITTER: Brix KV 

PROVIDER: S-EPMC8011552 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature