Prospective patient-reported symptom profiles associated with pediatric acute lymphoblastic leukemia relapse.

ABSTRACT:

Purpose

Despite improvements in frontline pediatric acute lymphoblastic leukemia (ALL) treatment, relapse remains a concern. Research in adult cancer patients suggests that patient-reported symptoms may predict survival, but the relationship between symptoms and relapse for pediatric ALL has received little attention.

Methods

Pediatric patients with ALL (age 2-18 years) and/or their primary caregivers completed symptom surveys at the end of induction, start of delayed intensification (DI), start of maintenance cycle 1 (MC1), and start of maintenance cycle 2 (MC2). Symptom clusters for co-occurring fatigue, pain, sleep disruptions, and nausea were defined using latent profile analysis. Hazard ratios (HR) and 95% confidence intervals (CI) for the association between symptom cl

SUBMITTER: Brown AL 

PROVIDER: S-EPMC8011637 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature