Alterations in T and B cell function persist in convalescent COVID-19 patients.

ABSTRACT:

Background

Emerging studies indicate that some coronavirus disease 2019 (COVID-19) patients suffer from persistent symptoms, including breathlessness and chronic fatigue; however, the long-term immune response in these patients presently remains ill-defined.

Methods

Here, we describe the phenotypic and functional characteristics of B and T cells in hospitalized COVID-19 patients during acute disease and at 3-6 months of convalescence.

Findings

We report that the alterations in B cell subsets observed in acute COVID-19 patients were largely recovered in convalescent patients. In contrast, T cells from convalescent patients displayed continued alterations with persistence of a cytotoxic program evident in CD8⁺ T cells as well as elevated production of type 1

SUBMITTER: Shuwa HA 

PROVIDER: S-EPMC8011689 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature