Personalized computational model quantifies heterogeneity in postprandial responses to oral glucose challenge.

ABSTRACT: Plasma glucose and insulin responses following an oral glucose challenge are representative of glucose tolerance and insulin resistance, key indicators of type 2 diabetes mellitus pathophysiology. A large heterogeneity in individuals' challenge test responses has been shown to underlie the effectiveness of lifestyle intervention. Currently, this heterogeneity is overlooked due to a lack of methods to quantify the interconnected dynamics in the glucose and insulin time-courses. Here, a physiology-based mathematical model of the human glucose-insulin system is personalized to elucidate the heterogeneity in individuals' responses using a large population of overweight/obese individuals (n = 738) from the DIOGenes study. The personalized models are derived from population level models through

SUBMITTER: Erdos B 

PROVIDER: S-EPMC8011733 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature