Pathoadaptation of the passerine-associated Salmonella enterica serovar Typhimurium lineage to the avian host.

ABSTRACT: Salmonella enterica is a diverse bacterial pathogen and a primary cause of human and animal infections. While many S. enterica serovars present a broad host-specificity, several specialized pathotypes have been adapted to colonize and cause disease in one or limited numbers of host species. The underlying mechanisms defining Salmonella host-specificity are far from understood. Here, we present genetic analysis, phenotypic characterization and virulence profiling of a monophasic S. enterica serovar Typhimurium strain that was isolated from several wild sparrows in Israel. Whole genome sequencing and complete assembly of its genome demonstrate a unique genetic signature that includes the integration of the BTP1 prophage, loss of the virulence plasmid, pSLT and pseudogene accumulation in mult

SUBMITTER: Cohen E 

PROVIDER: S-EPMC8011750 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature