Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies.

ABSTRACT: Gulf War Illness (GWI), a chronic multisymptom health problem, afflicts ~30% of veterans served in the first GW. Impaired brain function is among the most significant symptoms of GWI, which is typified by persistent cognitive and mood impairments, concentration problems, headaches, chronic fatigue, and musculoskeletal pain. This review aims to discuss findings from animal prototypes and veterans with GWI on mechanisms underlying its pathophysiology and emerging therapeutic strategies for alleviating brain dysfunction in GWI. Animal model studies have linked brain impairments to incessantly elevated oxidative stress, chronic inflammation, inhibitory interneuron loss, altered lipid metabolism and peroxisomes, mitochondrial dysfunction, modified expression of genes relevant to cognitive funct

SUBMITTER: Dickey B 

PROVIDER: S-EPMC8011829 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature