Proximate causes and consequences of intergenerational influences of salient sensory experience.

ABSTRACT: Salient sensory environments experienced by a parental generation can exert intergenerational influences on offspring. While these data provide an exciting new perspective on biological inheritance, questions remain about causes and consequences of intergenerational influences of salient sensory experience. We previously showed that exposing male mice to a salient olfactory experience, like olfactory fear conditioning, resulted in offspring demonstrating a sensitivity to the odor used to condition the paternal generation and possessing enhanced neuroanatomical representation for that odor. In this study, we first injected RNA extracted from sperm of male mice that underwent olfactory fear conditioning into naïve single-cell zygotes and found that adults that developed from these embryos ha

SUBMITTER: Aoued HS 

PROVIDER: S-EPMC8011833 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature