Persistent metabolomic alterations characterize chronic critical illness after severe trauma.

ABSTRACT:

Background

Following trauma, persistent inflammation, immunosuppression, and catabolism may characterize delayed recovery or failure to recover. Understanding the metabolic response associated with these adverse outcomes may facilitate earlier identification and intervention. We characterized the metabolic profiles of trauma victims who died or developed chronic critical illness (CCI) and hypothesized that differences would be evident within 1-week postinjury.

Methods

Venous blood samples from trauma victims with shock who survived at least 7 days were analyzed using mass spectrometry. Subjects who died or developed CCI (intensive care unit length of stay of ≥14 days with persistent organ dysfunction) were compared with subjects who recovered rapidly (intensive care unit len

SUBMITTER: Horn DL 

PROVIDER: S-EPMC8011937 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature