Immunologic aspects of viral therapy for glioblastoma and implications for interactions with immunotherapies.

ABSTRACT:

Introduction

The treatment for glioblastoma (GBM) has remained unchanged for the past decade, with only minimal improvements in patient survival. As a result, novel treatments are needed to combat this devastating disease. Immunotherapies are treatments that stimulate the immune system to attack tumor cells and can be either local or systemically delivered. Viral treatments can lead to direct tumor cell death through their natural lifecycle or through the delivery of a suicide gene, with the potential to generate an anti-tumor immune response, making them interesting candidates for combinatorial treatment with immunotherapy.

Methods

We review the current literature surrounding the interactions between oncolytic viruses and the immune system as well as the use of oncolytic vi

SUBMITTER: Haddad AF 

PROVIDER: S-EPMC8011939 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature