Collaborative Cross mice reveal extreme epilepsy phenotypes and genetic loci for seizure susceptibility.

ABSTRACT:

Objective

Animal studies remain essential for understanding mechanisms of epilepsy and identifying new therapeutic targets. However, existing animal models of epilepsy do not reflect the high level of genetic diversity found in the human population. The Collaborative Cross (CC) population is a genetically diverse recombinant inbred panel of mice. The CC offers large genotypic and phenotypic diversity, inbred strains with stable genomes that allow for repeated phenotypic measurements, and genomic tools including whole genome sequence to identify candidate genes and candidate variants.

Methods

We evaluated multiple complex epileptic traits in a sampling of 35 CC inbred strains using the flurothyl-induced seizure and kindling paradigm. We created an F2 population of 297 mice wi

SUBMITTER: Gu B 

PROVIDER: S-EPMC8011945 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature