Modeling Psychiatric Disorder Biology with Stem Cells.

ABSTRACT:

Purpose of review

We review the ways in which stem cells are used in psychiatric disease research, including the related advances in gene editing and directed cell differentiation.

Recent findings

The recent development of induced pluripotent stem cell (iPSC) technologies has created new possibilities for the study of psychiatric disease. iPSCs can be derived from patients or controls and differentiated to an array of neuronal and non-neuronal cell types. Their genomes can be edited as desired, and they can be assessed for a variety of phenotypes. This makes them especially interesting for studying genetic variation, which is particularly useful today now that our knowledge on the genetics of psychiatric disease is quickly expanding. The recent advances in cell engineering h

SUBMITTER: Das D 

PROVIDER: S-EPMC8011956 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature