4D Multimodal Nanomedicines Made of Nonequilibrium Au-Fe Alloy Nanoparticles.

ABSTRACT: Several examples of nanosized therapeutic and imaging agents have been proposed to date, yet for most of them there is a low chance of clinical translation due to long-term in vivo retention and toxicity risks. The realization of nanoagents that can be removed from the body after use remains thus a great challenge. Here, we demonstrate that nonequilibrium gold-iron alloys behave as shape-morphing nanocrystals with the properties of self-degradable multifunctional nanomedicines. DFT calculations combined with mixing enthalpy-weighted alloying simulations predict that Au-Fe solid solutions can exhibit self-degradation in an aqueous environment if the Fe content exceeds a threshold that depends upon element topology in the nanocrystals. Exploiting a laser-assisted synthesis route, we e

SUBMITTER: Torresan V 

PROVIDER: S-EPMC8011985 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature