Optimization of phase dispersion enables broadband excitation without homonuclear coupling artifacts.

ABSTRACT: In NMR spectroscopy, many specialized shaped pulses are available for broadband excitation, beyond the bandwidth of conventional high-powered hard pulses. These shaped pulses typically have long duration. However, long-duration pulses are unsuitable for spectra containing significant homonuclear couplings, such as polyfluorinated compounds in ¹⁹F NMR. J-coupling evolution during the excitation pulse leads to spectral artifacts and incorrect peak integrals. Here, we report an approach to optimal control pulse design which significantly reduces the pulse length required to excite large bandwidths of chemical shift frequencies. The target state phase is not chosen beforehand but is instead only constrained to be linearly dependent on offset frequency. The first-order phase of the t

SUBMITTER: Coote P 

PROVIDER: S-EPMC8012116 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature