Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.

ABSTRACT: The human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To characterize the earliest stages of human brain development, we performed single-cell RNA-sequencing across regions of the developing human brain, including the telencephalon, diencephalon, midbrain, hindbrain and cerebellum. We identify nine progenitor populations physically proximal to the telencephalon, suggesting more heterogeneity than previously described, including a highly prevalent mesenchymal-like population that disappears once neurogenesis begins. Comparison of human and mouse progenitor populations at corresponding stages identifies two progenitor clusters that are enriched in the early stages of human corti

SUBMITTER: Eze UC 

PROVIDER: S-EPMC8012207 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature