Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults.

ABSTRACT:

Introduction

The biological mechanisms linking mild cognitive impairment (MCI) and major depressive disorder are not well understood. We investigated whether molecular senescence changes in older adults are associated with a history of major depressive disorder (MDD) or MCI.

Methods

We included 371 participants: 167 with MCI; 62 cognitively normal with a history of MDD; 97 with MDD+MCI; and 45 cognitively unimpaired (CU) without a history of MDD. The candidate Senescence-Associated Secretory Phenotype (SASP) biomarkers were measured in the plasma using a customized LUMINEX assay.

Results

The MDD+MCI group had a higher SASP index than the other groups (P < .001). A higher SASP index was significantly associated with worse global cognitive performance, executive

SUBMITTER: Diniz BS 

PROVIDER: S-EPMC8012242 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature