Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease.

ABSTRACT:

Background

Neuropsychiatric symptoms (NPS) are frequent in aging and Alzheimer's disease (AD). Here we study the relationship between NPS and AD pathologies in vivo.

Method

Two hundred and twenty-one individuals from the TRIAD cohort (143 cognitively unimpaired, 52 mild cognitive impairment, and 26 AD) underwent [¹⁸F]MK6240-tau-positron emission tomography (PET), [¹⁸F]AZD4694-amyloid-PET, magnetic resonance imaging, and neuropsychological evaluations. Spearman correlations and voxel-based regression models evaluated the relationship between Neuropsychiatric Inventory Questionnaire (NPI-Q) scores, and tau-PET, amyloid-PET, and voxel-based morphometry.

Results

Fifty percent of individuals presented NPS; these correlated with tau, not amyloid beta o

SUBMITTER: Tissot C 

PROVIDER: S-EPMC8012244 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature