HIV Viremia and Risk of Stroke Among People Living with HIV Who Are Using Antiretroviral Therapy.

ABSTRACT:

Background

Rates of stroke are higher in people living with HIV compared with age-matched uninfected individuals. Causes of elevated stroke risk, including the role of viremia, are poorly defined.

Methods

Between 1 January 2006 and 31 December 2014, we identified incident strokes among people living with HIV on antiretroviral therapy at five sites across the United States. We considered three parameterizations of viral load (VL) including (1) baseline (most recent VL before study entry), (2) time-updated, and (3) cumulative VL (copy-days/mL of virus). We used Cox proportional hazards models to estimate hazard ratios (HRs) for stroke risk comparing the 75th percentile ("high VL") to the 25th percentile ("low VL") of baseline and time-updated VL. We used marginal structural Co

SUBMITTER: Harding BN 

PROVIDER: S-EPMC8012252 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature