In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori.

ABSTRACT: Helicobacter pylori infection is a major etiological factor in gastric diseases. However, clinical antibiotic therapy for H. pylori is limited by continuously decreased therapeutic efficacy and side effects to symbiotic bacteria. Herein, we develop an in vivo activatable pH-responsive graphitic nanozyme, PtCo@Graphene (PtCo@G), for selective treatment of H. pylori. Such nanozymes can resist gastric acid corrosion, exhibit oxidase-like activity to stably generate reactive oxygen species only in acidic gastric milieu and demonstrate superior selective bactericidal property. C₁₈-PEG_n-Benzeneboronic acid molecules are modified on PtCo@G, improving its targeting capability. Under acidic gastric pH, graphitic nanozymes show notable bactericidal activity toward H. pylori, wh

SUBMITTER: Zhang L 

PROVIDER: S-EPMC8012368 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature