Fetal brain growth and risk of postnatal white matter injury in critical congenital heart disease.

ABSTRACT:

Objective

To test the hypothesis that delayed brain development in fetuses with d-transposition of the great arteries or hypoplastic left heart syndrome heightens their postnatal susceptibility to acquired white matter injury.

Methods

This is a cohort study across 3 sites. Subjects underwent fetal (third trimester) and neonatal preoperative magnetic resonance imaging of the brain to measure total brain volume as a measure of brain maturity and the presence of acquired white matter injury after birth. White matter injury was categorized as no-mild or moderate-severe based on validated grading criteria. Comparisons were made between the injury groups.

Results

A total of 63 subjects were enrolled (d-transposition of the great arteries: 37; hypoplastic left heart syndrome

SUBMITTER: Peyvandi S 

PROVIDER: S-EPMC8012393 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature